Nausea and glioblastoma
Rikkunshito (RKT) is prepared from 8 raw herbs: Atractylodes laneae rhizoma, Ginseng radix, Pinelliae tuber, Hoelen, Zizyphi fructus, Aurantii nobilis pericarpium, Glycyrrhizae radix and Zingiberis rhizoma. RKT is widely prescribed in Japan for patients with a variety of gastrointestinal symptoms such as nausea, vomiting and anorexia.
In a randomized, placebo-controlled RKT study, gastric emptying and gastrointestinal symptoms were evaluated in 42 patients with functional dyspepsia. Subjects were randomly assigned to oral treatment with 2.5 g RKT three times a day (22 subjects) or placebo (20 subjects). Gastric emptying was measured by the acetaminophen absorption method. After 7 days of treatment, gastric emptying was significantly accelerated and gastrointestinal symptoms were significantly reduced in patients treated with RKT, indicating that RKT has a prokinetic action on gastric emptying and may be useful in the treatment of functional dyspepsia. (Tatsuta M, Iishi H. Effect of treatment with liu-jun-zi-tang (TJ43) on gastric emptying and gastrointestinal symptoms in dyspeptic patients. Aliment Pharmacol Ther 1993;7:459-462)
The effect of RKT on symptoms and gastric myoelectric activity has been evaluated in dyspeptic patients whose symptoms persist for more than 1 year after gastrointestinal surgery. All patients showed symptom relief with RKT administration, with a significant decrease in mean symptom scores, which were maintained over a 1-month period (P. 0.0001). (Yagi M, Homma S, Kubota M, Iinuma Y, Kanada S, Kinoshita Y, Ohtaki M, Yamazaki S, Murata H. The herbal medicine Rikkunshi-to stimulates and coordinates the gastric myoelectric activity in post-operative dyspeptic children after gastrointestinal surgery. Pediatr Surg Int 2004;19:760-765.)
Prophylactic effect of rikkunshito, an herbal medicine, for chemotherapy-induced nausea in thoracic cancer patients receiving carboplatin-based chemotherapy C Hirose, H Iihara, N Funaguchi, J Endo… - Die Pharmazie-An …, 2019 - ingentaconnect.com
Japanese herbal medicine rikkunshito increases food intake and plasma acylated ghrelin levels in patients with esophageal cancer treated by cisplatin … Y Hamai, T Yoshiya, J Hihara, M Emi… - Journal of thoracic …, 2019 - ncbi.nlm.nih.gov
Effects of Rikkunshito, a Japanese traditional herbal medicine, on anorexia and plasma-acylated ghrelin levels in lung cancer patients undergoing cisplatin … T Yoshiya, T Mimae, M Ito, S Sasada, Y Tsutani… - Investigational new …, 2019 – Springer
Rikkunshito for upper gastrointestinal symptoms: A systematic review and meta-analysis N Hoshino, D Nishizaki, K Hida, K Obama… - … therapies in medicine, 2019 - Elsevier