Alteraciones genéticas frecuentes del glioblastoma

EPHA3: Regulation of adhesive and repulsive mechanisms including cellmotility and adhesion

EGFR: Regulation of processes involved in cell growth, division and survival

MGMT: Prevention of mismatch errors

CDKN2A: Regulation of cell cycle and retinoblastoma activation

PTEN: Regulation of cell signalling. lnvolved in cell proliferation and survival

PIK3CA: Regulation of processes involvedin cell growth, division and survival

PDGFRA: Regulation of processes involvedin cell growth, division and survival

IDH1: Production of NADPH

MDM2: Regulation of p53 activity

MET: Regulation of proliferaiton, survival and motility

SF/HGF: Activating ligand for HGFR/c-MET. Tumour growth and angiogenesis

VEGF: Promotion of angiogenesis


Bibliografía

Comprehensive genetic alteration profiling in primary and recurrent glioblastoma

BK Neilsen, R Sleightholm, R McComb… - Journal of neuro …, 2019 - Springer

Whole‐exome sequencing revealed mutational profiles of giant cell glioblastomas

Z Shi, KKW Li, JSH Kwan, RR Yang… - Brain …, 2019 - Wiley Online Library

The genetic landscape of gliomas arising after therapeutic radiation

GY López, J Van Ziffle, C Onodera, JP Grenert… - Acta …, 2019 - Springer

Intratumoral genetic and functional heterogeneity in pediatric glioblastoma

M Hoffman, AH Gillmor, DJ Kunz, MJ Johnston… - Cancer research, 2019 - AACR

Genetic, Epigenetic, and Immunologic Profiling of MMR-Deficient Relapsed Glioblastoma

S Indraccolo, G Lombardi, M Fassan, L Pasqualini… - Clinical Cancer …, 2019 - AACR

A systematic review on the current radiogenomics studies in glioblastomas

S Bisdas, E Ioannidou, F D'Arco - Hellenic Journal οf Radiology, 2019 - hjradiology.org

An integrative model of cellular states, plasticity, and genetics for glioblastoma

C Neftel, J Laffy, MG Filbin, T Hara, ME Shore… - Cell, 2019 - Elsevier


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Página actualizada el 17 de Septiembre de 2020

Málaga, España (Spain)

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